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Evidence for a Dopaminergic Deficit in Sporadic Amyoptrophic Lateral Sclerosis on Positron Emission Scanning Lancet 324:1016-1018, Takahashi,H.,et al, 1993 See this aricle in Pubmed Article Abstract Although rare,the chronic neurodegenerative disorders amyotrophic lateral sclerosis(ALS)and idiopathic parkinsonism coexist to a greater degree than expected by chance.This suggests that patients with ALS may have subclinical lesions of the nigrostriatal dopaminergic pathway.To study this hypothesis,we did positron emission tomography with 6-fluorodopa on l6 patients with sporadic ALS and without extrapyramidal disease,and compared the results with age-matched controls.We found a significant progressive fall in 6-fluorodopa uptake with time since diagnosis,and reduced dopaminergic function in 3 patients with ALS of long duration.This supports the hypothesis that ALS and IP may share pathogenesis and perhaps etiology.

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